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In vivo , in the hippocampal tissues of mice exposed to PS-MPs, there was a significant increase in the mRNA expression levels of inflammation-related genes ( Tnf-a , Il-1b , Il-6 , Cxcl10 , and Mcp-1 ), indicating heightened inflammatory responses ( In vitro studies indicate PS has the capacity to bind to and activate BV2 microglial cells, thereby inducing pro-inflammatory reactions and activating inflammatory pathways, such as the NF-κB pathway, which results in the production of pro-inflammatory cytokines (Li et al., 2024)

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