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doi: 10.1093/humrep/dez243 217 Martín-RomeroFJMiguel-LasobrasEMDomínguez-ArroyoJAGonzález-CarreraEÁlvarezIS

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However, when ROS levels rise beyond the capacity of antioxidants, they can damage cellular macromolecules, disrupt normal cell functions, trigger mitochondria to produce pro-apoptotic proteins, and ultimately lead to the apoptosis of central nervous system neurons (Schieber and Chandel, 2014)