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Antioxidant responses, particularly those initiated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2) signaling, have been demonstrated to play a pivotal role in restoring redox balance and constraining the progression of fibrosis or HCC (Kundu and Surh 2010)
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Subsequently, the dehydrogenases/reductases in various metabolic pathways convert NADP + into NADPH
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