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Consistently documented IGF-1 elevations of 40-79% across study populations confirm that this liver-mediated downstream effect is robust and reproducible [3, 10, 16]

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[22] reviewed the characteristics of the nasal delivery devices in general and the aerosol generation to achieve the clinical target of nasal drug delivery to the nose cavity, whether the substance in question has local action, is intended for systemic absorption, N-to-B transport, or a combination [22]