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[5] The pathophysiology of anaphylaxis and anaphylactoid reactions stems from the effect of histamine on vascular and bronchial smooth muscle leading to cutaneous vasodilation and third-spacing (hives, rash, pruritis), bronchospasm (wheezing), and reduced systemic vascular resistance (tachycardia, hypotension)
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Proteins highly engaged by SCLA compounds were less labelled by subsequent treatment with an alkyne-modified probe, thereby showing a reduced signal following click chemistry, streptavidin pulldown and quantitative label-free MS (Fig
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